This apparent disconnect may be explained by upregulation of FTH1-ps2 , a pseudogene known to act as a competing endogenous RNA (ceRNA), stabilizing FTH1 mRNA by sequestering inhibitory miRNAs (50)
493 In terms of chemotherapy sensitization, lactate has been found to confer chemoresistance by increasing the expression of multidrug resistance-associated protein 1 (MRP1, encoded by ATP-binding cassette sub-family C member 1 (ABCC1)), which induces drug efflux from cells
Krajewska M, Zapata JM, Meinhold-Heerlein I, Hedayat H, Monks A, Bettendorf H, Shabaik A, Bubendorf L, Kallioniemi OP, Kim H, Reifenberger G, Reed JC, Krajewski S (2002) Expression of Bcl-2 family member Bid in normal and malignant tissues
Considerations Human data is limited, with most evidence from animal studies and user reports